Journal article
Neuropsychological and Socio-Occupational Functioning in Young Psychiatric Outpatients: A Longitudinal Investigation
RSC Lee, DF Hermens, MA Redoblado-Hodge, SL Naismith, MA Porter, M Kaur, D White, EM Scott, IB Hickie
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2013
Abstract
Background: Clinical symptoms and neuropsychological deficits are longitudinally associated with functional outcome in chronic psychiatric cohorts. The current study extended these findings to young and early-course psychiatric outpatients, with the aim of identifying cognitive markers that predict later socio-occupational functioning. Methods: At baseline, 183 young psychiatric outpatients were assessed. Ninety-three returned for follow-up (M = 21.6 years old; SD = 4.5) with an average re-assessment interval of 21.6 months (SD = 7.0), and primary diagnoses of major depressive disorder (n = 34), bipolar disorder (n = 29), or psychosis (n = 30). The primary outcome measure was cross-validated..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
IBH was funded by an NHMRC Program Grant (No. 566529) and Australian Fellowship (No. 511921). DFH was supported by a grant from NSW Health Mental Health and Drug & Alcohol Office. SLN was funded by an NHMRC Clinical Research Fellowship (No. 402864). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors have read the journal's policy and have the following conflicts. IBH was funded by an NHMRC Program Grant and Australia Fellowship. DFH was supported by a grant from NSW Health Mental Health and Drug & Alcohol Office. SLN was funded by an NHMRC Career Development Award. IBH has led projects for health professionals and the community supported by governmental, community agency, and drug industry partners (Wyeth, Eli Lily, Servier, Pfizer, Astra Zeneca) for the identification and management of depression and anxiety. He has served on advisory boards convened by the drug industry in relation to specific antidepressants, including nefazodone, duloxetine, and desvenlafaxine, and has participated in a multicenter clinical trial of agomelatine effects on sleep architecture in depression. He has participated in Servier-sponsored educational programs related to circadian-based therapies. DFH has previously received honoraria for educational seminars from Janssen-Cilag. MARH has received financial support from Eli-Lily for a multisite trial of cognitive remediation in psychosis, and is a co-investigator in an Australian Rotary funded project investigating the synergistic effects of cognitive remediation and vocational training in psychosis. She was also a co-investigator in a drug trial with Novartis pharmaceutical who sponsored overseas travel in 2011, and was also involved in NHMRC funded trials in psychosis. EMS has received honoraria for educational seminars related to the clinical management of depressive disorders supported by Servier and Eli-Lilly pharmaceuticals. She has also participated in a national advisory board for the antidepressant compound Pristiq, manufactured by Pfizer. These funding agencies had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.